COlonization, Succession and Evolution of Human Gastrointestinal MICrobiome from Birth to Infancy - An Integrative High-Resolution Molecular Observational Study Comparing Neonates at Increased Risk for Cardiovascular and Metabolic Disease in Adulthood to Healthy Controls in Luxembourg

Study Objective

To identify differences in gut flora and their impact on energy uptake and utilisation (through system approach including metagenomics, transcriptomics, metabolomics) between normal healthy neonates versus neonates born with low birth weight, and thus at high risk for adult metabolic disease (diabetes and other diseases)

Participation conditions

Inclusion criteria

Patients:
•Healthy term neonates without known risk factors (control group).
•Term neonates after CS (increased risk of obesity in later life).
•SGA babies and children of diabetic mothers (increased risk of obesity and insulin
resistance in later life).
•Low birth weight infants (increased risk of obesity and insulin resistance in later life).
•Mothers.
Total number of subjects: 120 babies + 120 mothers.

Centre Hospitalier de Luxembourg (CHL)